Deep Dive In Vitiligo

Do AI Models Really Understand the World of Vitiligo? (Ep. 26)

Do large language models like ChatGPT or Deep Seek actually understand the world, or are they just really good at faking it?
In this episode, we dig into the debate: are LLMs building genuine “world models” or just recycling patterns from massive datasets? We’ll explore real-world AI fails, like the skin lesion detector that linked rulers to cancer, and what that means for AI in diagnosing conditions like vitiligo.
Tune in to get the real story behind AI’s so-called “understanding.”
Suggested reading:
Do AI Models Really Understand the World of Vitiligo?
Cheaper AI, Higher Stakes: What Startups and Big Pharma Must Know
 

Inside Vitiligo Clinical Trials: Why, What and How? (Ep. 25)

Today, we’re diving into the cutting-edge world of vitiligo research. We’re talking about the latest clinical trials, game-changing treatments like Opzelura and JAK inhibitors, and why getting involved in these trials isn’t just about early access—it’s about making a real impact.
Thinking about joining a trial? We’ll cover what you need to know—eligibility, what to expect, and why talking to your doctor is key.
Suggested reading: 
Clinical Trials: An Important Step in Drug Development
List of current Clinical Trials in Vitiligo
 
 

From Lost to Found: 50 Years of the National Vitiligo Act, 10 Years of Advocacy Revival (Ep. 24)

In this episode, we uncover the forgotten history of the National Vitiligo Control Act—a bold bill from the 1970s aimed at transforming lives affected by vitiligo. Thought lost to time, it was rediscovered in 2015 by Yan Valle, CEO of the Vitiligo Research Foundation, reigniting hope and advocacy.
Join us as we explore:🎙️ The origins of the Act and its champion, Congressman Parren J. Mitchell, who battled vitiligo himself.🎙️ The emotional rediscovery of the Act and its impact on the vitiligo community.🎙️ How a piece of 1975 legislation echoed in 2017 and 2024.🎙️ The controversy over shifting the proposed October 17th date from World Vitiligo Day on June 25th.
This episode isn’t just about legislation—it’s about the passion and persistence that sparked a movement. Whether you’re connected to the vitiligo community or curious about the power of advocacy, this story will inspire you.
Suggested reading: 
From Lost to Found: 50 Years of the National Vitiligo Act
The Entire History of the World Vitiligo Day
 

Vitiligo and Sleep: Breaking the Vicious Circle (Ep. 23)

Vitiligo is more than a skin condition—it affects identity, confidence, and emotional well-being. The stress and anxiety linked to vitiligo can disrupt sleep, creating a cycle of restlessness and fatigue. High cortisol levels from stress interfere with the sleep-wake cycle, while autoimmune inflammation and emotional distress worsen insomnia.
But what if breaking that vicious cycle could improve both mental health and skin healing?
In this episode of Deep Dive in Vitiligo, we explore how stress, inflammation, and mental health challenges contribute to poor sleep in people with vitiligo—and how we can fix this.  
Join us as we uncover practical strategies to restore restful nights and regain control—not just over your skin but over your well-being, too.

Behavioral Epigenetics: How Stress Affects Vitiligo (Ep. 22)

Today, we explore how everyday life experiences can tweak gene expression, influence health, and even ripple through generations.
From stress management to the science behind skin conditions like vitiligo, we break it down with wit, wisdom, and practical takeaways.
Tune in to learn how your choices today might shape a healthier tomorrow for you and your future offspring!

ChatGPT vs. Doctors: The Promise and Pitfalls of AI in Medical Diagnosis (Ep. 21)

Two new studies reveal the promise and challenges of using AI-chatbots in healthcare.  
In one study, ChatGPT outperformed doctors in diagnosing illnesses from case histories, with a 90% accuracy rate compared to doctors' 76%. However, it also showed that many doctors stick to their own judgment and don’t fully utilize AI’s potential.  
Another study focused on pharmacy settings found ChatGPT struggled with complex medical questions, often providing inaccurate or even made-up answers.  
This episode unpacks what these findings mean for the future of healthcare. Can AI become a trusted partner for doctors? What needs to change to make it work—and could embracing AI save lives? Let’s dive in.  

More Than Our Skin: 5 Women’s Journeys with Vitiligo (Ep. 20)

In this inspiring episode, we dive into More Than Our Skin, the award-winning documentary that’s changing how the world sees vitiligo. Through the powerful stories of five remarkable women, we explore resilience, self-acceptance, and the beauty of embracing our differences. Along the way, we’ll discuss the latest in vitiligo advocacy, medical breakthroughs, and the ripple effect this film is creating in the world.
Read more: Beneath the Spots: A Journey of Courage, Beauty, and Resilience

Vitiligo’s White Armour: A Shield Against Mortality & Diseases? (Ep. 19)

Could vitiligo hold the key to a longer, healthier life? Groundbreaking research from Korea reveals that individuals with vitiligo have lower risks of major diseases like cancer, heart issues, and infections.
In this episode, we explore the science behind these findings, from immune "white armor" to enhanced cellular cleanup.
Join us as we challenge the narrative and uncover the hidden strengths of this misunderstood condition. Stay curious, inspired, and ready to rethink vitiligo’s role in health!
Start the year 2025 by staying curious, informed, and inspired—this is one conversation you don’t want to miss!
Suggested reading:
Vitiligo’s White Armour: A Shield Against Mortality & Diseases?

What Cryptocurrencies Can Teach Us About Support Networks (Ep. 18)

Starting a vitiligo support group is a meaningful way to connect people, share experiences, and build a strong sense of community. In 2025, the focus should shift to creating local groups rather than relying on a centralized network.
Centralized systems, like a single online group, risk power imbalances, where decision-making is concentrated among a few.
This is similar to the pitfalls of centralized digital currencies controlled by authoritarian states, which can impose unfair restrictions. In contrast, decentralized models foster fairness, inclusivity, and autonomy, ensuring diverse voices are heard.
Decentralized support groups also enhance resilience. If one group encounters challenges, others can continue operating, maintaining stability—much like distributed systems used in banking and defense.
The success of World Vitiligo Day, with its decentralized structure by design, demonstrates the power of this approach, achieving greater global visibility than centralized campaigns like World Psoriasis Day, as supported by Google Trends data.
The VR Foundation provides a cache of resources and guidance for starting local groups. Additionally, Valarie Molyneaux and the team at VITFriends serve as inspiring examples of how to build a thriving network of vitiligo support groups.
Suggested reading:
How To Start A Vitiligo Support Group: A Step-by-Step Guide

Pharma, Startups, and AI: From 2024 to 2025 (Ep. 17)

In the 17th episode of Deep Dive in Vitiligo, we wrap up the year with a thoughtful analysis of the vitiligo drug development landscape, exploring the breakthroughs, challenges, and opportunities shaping the future of care. From pharmaceutical giants to AI-driven startups, we delve into the science, strategies, and collaborations pushing the boundaries of what’s possible.
The Titans of Treatment 
Leading the charge is Incyte with Opzelura, the first FDA-approved topical treatment, alongside Pfizer, advancing its oral drug Litfulo through Phase 3 trials. These major players are setting new benchmarks in targeted therapies, but as the field grows, questions remain about accessibility, affordability, and long-term efficacy.
Innovation and Collaboration 
Smaller players are also making waves. One standout is Skinopathy, a Canadian company innovating in AI-driven care. In collaboration with the VRF, Skinopathy is working to develop a comprehensive AI-care system for vitiligo—combining diagnostics, treatment tracking, and patient management tools. This partnership demonstrates how AI, when guided by robust expertise, has the potential to empower patients and enhance care.
The Market at a Glance
The vitiligo treatment market is projected to grow to $822.75 million by 2028, driven by increasing awareness, rising prevalence, and substantial R&D investment. Yet, this growth isn’t without challenges, from regulatory hurdles to ensuring equitable access.
A Multifaceted Approach
We explore a wide array of players and their approaches:
Amgen and its IL-15 signaling blocker AMG 714 
Merck, leveraging its acquisition of Pandion Therapeutics for regulatory T cell expansion with MK-6194 
AbbVie, investigating small molecule inhibitors for immune-mediated diseases
Vyne Therapeutics and its novel BET inhibitor VYN201 
Ahammune Biosciences, advancing AB1001, targeting T cell activation to halt vitiligo’s spread.
Why It Matters 
At the intersection of science, technology, and patient care lies a vital question: How do we ensure that these advancements translate into meaningful outcomes for those living with vitiligo? This episode highlights the importance of balancing innovation with accessibility and the role of collaboration in creating solutions that serve patients, providers, and the broader community.
Tune in as we explore the future of vitiligo treatments and the transformative potential of science and technology working together.
Listen now, and be part of the conversation shaping the next chapter in vitiligo care.
Key moments
- [00:00:00] Welcome and Introduction: Setting the stage for an in-depth dive into vitiligo drug development. - [00:00:42] Market Outlook: Vitiligo treatment market poised to reach $2 billion by 2026. - [00:01:09] Industry Leaders: Incyte and their FDA-approved drug Opzelura—what sets it apart. - [00:05:12] Pfizer's Competitive Edge: Lituflo’s oral formulation and its game-changing potential. - [00:10:27] Innovation Highlights: Amgen's AMG 714, targeting IL-15 for immune system regulation. - [00:15:33] Inclusivity in Focus: Clinuvel’s unique approach for patients with darker skin tones. - [00:18:40] Futuristic Therapies: Temprion Therapeutics and DNA-based whole-body repigmentation. - [00:23:19] Beyond Drugs: Skinopathy’s AI-powered diagnostics transforming vitiligo care. - [00:27:08] Emotional Impact: Vitiligo's effects on self-esteem and the importance of patient advocacy. - [00:30:00] Risks and Trade-offs: Navigating long-term concerns and immune suppression challenges. - [00:35:12] Looking Ahead: Personalized medicine, AI, and a collaborative ecosystem driving hope.
Suggested reading:
Vitiligo Drug Pipeline Analysis and Market Insights
The Real Price Tag of Treating Vitiligo: What You Need to Know